Sysmex XN-31

The fight against malaria starts with diagnostics

• Accurate enumeration and direct detection of malaria-infected red blood cells (MI-RBC)
• Detection of all Plasmodium species capable of infecting human red blood cells
• Limit of detection is 20 MI-RBC/µL
• Measurement of the complete blood count
• Up to 60 samples per hour; sample aspiration volume 60 µL (load and go – no sample preparation)

Malaria remains one of the most important public health concerns globally with more than 3 billion people in 85 countries at risk of infection, according to the 2023 WHO report.

Early and accurate diagnosis of malaria is vital in the fight against the disease, so that specific treatment can be initiated to prevent complications and reduce mortality. The Sysmex XN-31 automated analyser can detect and count malaria-infected red blood cells (MI-RBC) within one minute with excellent sensitivity and specificity [1].

[1] Pillay E et al. (2019): Malar J. 18(1): 15.

Diagnostic support

• Be confident fighting malaria: accurate enumeration and direct detection of malaria-infected red blood cells (MI-RBC) facilitates reliable diagnosis.
• Consistent standard limit of quantification (20 MI-RBC/μL) independent of the operator’s skill.
• Detection of all Plasmodium species capable of infecting human red blood cells.
• The high clinical sensitivity and accurate enumeration support the assessment of anti-malarial treatment.
• The concurrent CBC measurement provides clinicians with important information for clinical correlation.
  • Anaemia is a major contributor to mortality in malaria.
  • The degree of thrombocytopenia provides an indication of the severity of malaria.
  • The WBC count could be helpful to give an indication of other concurrent infections.

Workflow

• The XN-31 incorporates Sysmex’s proven technologies well established for the haematology analysers.
• By utilising this automated solution your lab can shorten the TAT while ensuring a highly sensitive detection of malaria-infected red blood cells (MI-RBC).
• Operating the analyser is easy and does not require a malaria expert.
• The integrated sampler allows high sample throughput and walk-away time.
• The MI-RBC parameters are stable and unaffected by room temperature, which enables the processing of specimens collected and transported appropriately from remote locations.
• Maintenance requirements are minimal whilst being very simple and easy to execute.
• The quality control material enables effective and reliable control of all diagnostic parameters of XN-31, including MI-RBC # and %.